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Treatment options in mast cell activation disorders

According to current knowledge, systemic mast cell activation diseases (MCAD) are not curable in the sense of eliminating the physical cause. A few cases of spontaneous remissions were reported to us (the disease disappeared "by itself"). However, in these rare cases the real cause as well as the reason for their disappearance are unclear.

Although incurable, there are good treatment options to get the annoying to very painful symptoms under control. Various therapeutic measures can be applied in combination to improve life quality significantly. Treatment options can be summarized into two categories:

1. Avoid mast-cell-activating triggers
2. Medication

Depending on the severity, not necessarily all of these various therapeutic options have to be followed, but the stricter one is keeping to it, the better is the condition. Every person affected has to find individually its ideal combination and extent of therapeutic measures. Partially also a daily adjustment of the therapy at the expected and current histamine exposure is useful.

Avoid mast-cell-activating triggers

Measures at the social level

The technological, social and cultural influences acting on the population (food, medication, pollution, ...) must be designed in a way that the frequency, duration and intensity of mast-cell-activating effects on the population are kept as low as possible. It should be as simple and attractive as possible to avoid triggers.

• The key players of the issue have to be sensitized (authorities, politicians, producers and suppliers of products)
• Education and training of health care professionals
• Exposure of the population to mast-cell-activating triggers has to be kept low. For example, on a legal level (food law, environmental law, pharmaceutical legislation) or with incentives
• Informing the population about mast cell activation and its consequences

Measures at the level of the single individual

The individual is – by a conscious way of life – able to avoid most of the mast-cell-activating triggers, as far as circumstances permitting. For example, by change of residence, a suitable choice of profession and workplace, leisure, nutrition, addictions etc. What triggers are to be avoided, can be found on the page Therapy > Triggers.

Medication

Various medicines and dietary supplements are available, as described on the page Therapy > Medicaments.

Guided tour: Go to page
Therapy > Triggers

Bibliography

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